Reach Us +44-1904-929220
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Atypical Presentation of Neuroleptic Malignant Syndrome in a Pediatric Patient

This is a case of a 16-year-old male with a history of attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), obsessive compulsive disorder (OCD), and bipolar disorder (BD) who presented to the emergency department with hypertension, tachycardia, rigidity, and altered mental status 2 months after the initiation of olanzapine. Symptoms were most consistent with Neuroleptic Malignant Syndrome (NMS). Neuroleptic Malignant Syndrome (NMS) a potentially fatal neurologic emergency generally precipitated by the use of neuroleptic agents. The clinical syndrome is characterized by mental status changes, fever, dysautonomia, and rigidity. While most cases of NMS are precipitated by “typical” neuroleptic agents such as haloperidol and fluphenazine other agents such as lower potency or “atypical” antipsychotic drugs have been implicated in the development of NMS as well. To our knowledge, this is the first reported pediatric case of NMS attributed by atypical or second-generation antipsychotics. Additionally, our patient did not exhibit the classic tetrad of clinical symptoms on presentation.


Yaphockun K, Corbett B and Conrad H

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+

Abstracted/Indexed in

  • Index Copernicus
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • WorldCat
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs
Flyer image